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VOL. 11, ISSUE 1 (2026)
Toxicological impact of Tartrazine on intestinal structure and hematological profiles: A mini review
Authors
G R Navdhinge, V T Dhurvey, A M Nagwanshi, A A Sharma
Abstract
Tartrazine (E102) is a widely used synthetic
lemon‑yellow azo dye prevalent in food, pharmaceutical, and cosmetic
products. Despite established acceptable daily intake (ADI) levels,
increasing evidence suggests that prolonged or excessive consumption may induce
toxicological effects. This review examines the impact of tartrazine on
hematological parameters and intestinal structure and function. The findings
indicate that tartrazine exposure causes dose‑ and duration‑dependent
alterations in hematological indices, including anemia, leukocytosis, changes
in erythrocyte indices, and immune dysregulation. Additionally, tartrazine
adversely affects intestinal morphology and function, manifesting as villus
atrophy, crypt degeneration, inflammatory cell infiltration, oxidative stress,
and impaired digestive enzyme activity. Mechanistic studies suggest
that oxidative stress, inflammatory pathways, genotoxicity, and immune
modulation contribute to these toxic effects. Several natural antioxidants, including
vitamin C, curcumin, garlic oil, honey, crocin, and plant extracts, have shown
protective potential against tartrazine‑induced toxicity. Overall, this review
highlights the potential health risks of chronic tartrazine consumption on the
intestinal health, hematological, biochemical parameters and protective
potential against the tartrazine induced toxicity.
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Pages:397-401
How to cite this article:
G R Navdhinge, V T Dhurvey, A M Nagwanshi, A A Sharma "Toxicological impact of Tartrazine on intestinal structure and hematological profiles: A mini review". International Journal of Entomology Research, Vol 11, Issue 1, 2026, Pages 397-401
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